Why would dnase 1 and alginate lyase be adjectives for treating cystic fibrosis?
Answers: First, a quick review of CF: Patients beside CF have "tacky mucus production as well as a smaller quantity competent immune system results in frequent lung infections, which are treated, though not other cured, by oral and intravenous antibiotics and other medications."
That anyone said, here is my best educated guess to answer your give somebody the third degree:
This from www.cysticfibrosismedicine.com on DNAse- "In 1990 Shak and colleagues cloned, sequenced and expressed a recombinant DNase 1 (rhDNase) and suggested that it may reduce the viscosity of CF sputum (Shak et al, 1990)." The tacky lung secretions are a ripe breeding ground for germs. If you decrease the viscosity of the secretion and thus make it easier for the long-suffering to clear, you could reduce lung infections.
Alginate lyase: This from PubMed- "Increased expression of the alginate lyase surrounded by mucoid strain 8830 led to alginate embarrassment and increased cell detachment."
From what I can gather, alginate binds Pseudomonas Aeruginosa to lung tissue. Pseudomonas is vastly often the culprit surrounded by CF exacerbations (increase in coughing, hallucination, sputum production, etc). So alginate lyase "lyses" or degrades the bond of to the tissue thus decreasing lung infection.
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