Do u know why fetal lung hypoplasia cause hydramnios?
Answers: No, I didn't. But I looked it up for you. And found this:
"For lung development to proceed generally, physical space in the fetal thorax must be mediocre, and amniotic fluid must be brought into the lung by fetal breathing movements, leading to distension of the developing lung. Several factor affect the volume and composition of the amniotic fluid, including the following:
Volume and pressure
The volume of liquid within the lung is determined by the net rate at which soft is secreted across the pulmonary epithelium (4-5 mL/kg/h) and the rate at which it flows from the trachea into the fetal pharynx. The pressure in the fetal trachea is in general about 2 mm Hg high than in the amniotic fluid, thus preventing outflow of fetal lung fluid.
Any alteration surrounded by the critical volume and pressure relationships of amniotic fluid in the trachea and lung during the canalicular stage of fetal lung nouns at 15-28 weeks' gestation can induce hypoplasia.
Composition of lung fluid
Lung development is regulated by several transcription factor, such as thyroid transcription factor 1 (TTF-1) family, hepatocyte nuclear family unit, and peptide growth factors.
The presence of growth factor in amniotic fluid indicates that lung nouns is not solely a pressure phenomenon. Signals from these growth factors are integrated beside environmental influences, such as lung fluid volume and hyperoxia, to cause cellular proliferation and differentiation. A switch component is the branching morphogenesis that occurs as a result of an interaction between the endodermal and mesenchymal components. Growth factor are produced by mesenchymal tissue and are present in amniotic fluid. Therefore, the expression of several growth factors and their receptors, adjectives of which affect fetal lung development, is temporally and spatially regulated. "
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