Iam a PCOS merciful, suggest me which tablet is more beneficial, tab.clomid or tab.letrozole.?
Answers: Clomid (generic clomiphene) have been around longer, but letrozole (brand pet name Femara) appears to have a smaller amount side effects and is considered very safe and sound.
The two articles quoted below have different opinion on which is more effective. One say we don't know, the other that it is letrozole, but not to a level of resolve, or statistical significance, because the study didn't look at enough patients to be sure that one be better than the other.
Iwould say that you should try them respectively for several months if necessary. Clomid 100mg seem like a okay drug and dose, but I wouldn't keep varying back and forth.
So, possibly you should try the letrozole two more months, and failing that, try the higher dose Clomid for a few months.
From http://www.ivf-et.com/tlc/fact_pcos.html
"(Femara) Letrozole belongs to a group of drugs particular as aromatase inhibitors. While indicated for long term treatment of breast cancer, when letrozole is used within a short time regimen similar to clomiphene, it may promote majority follicle and ovulation. The cost of letrozole is comparable to clomiphene and like clomiphene, the risk of hyperstimulation is low near usually no more than 2 mature follicles produced.
"Letrozole is swiftly cleared from the bloodstream and it appears to have a large safety profile. The reported side effects are much smaller number than clomiphene and the negative effects of clomiphene on the cervical mucus and uterine inside layer are avoided. The jury is still out about their worth in PCOS and especially within those that have bungled to have follicle nouns of clomiphene."
This article (research) also suggests that letrozole is more effective:
http://humrep.oxfordjournals.org/cgi/con...
Efficacy of combined metformin–letrozole surrounded by comparison with metformin–clomiphene citrate within clomiphene-resistant infertile women with polycystic ovarian disease:
"RESULTS: Mean total E2 and E2 per grow follicle were significantly difficult in clomiphene group lacking a difference in scrounging number of mature follicles >18 mm and ovulation rate. Endometrial solidity was significantly better in letrozole group. The pregnancy rate surrounded by letrozole group (10 patients, 34.50%) as compared with clomiphene group (5 patients, 16.67%) did not show significant difference, whereas full-term pregnancies be higher contained by letrozole group [10 patients (34.50%) versus 3 patients (10%)].
"CONCLUSION: In clomiphene-resistant PCOS patients, the combination of letrozole and metformin leads to greater full-term pregnancies."
Clomiphene is used to induce ovulation (egg production) in women who do not produce ova (eggs) but want to become pregnant. Clomiphene is in a class of medication called ovulatory stimulants. It works similarly to estrogen, a womanly hormone that causes eggs to develop surrounded by the ovaries and be released.
Letrozole is used to treat certain types of breast cancer within women. Female hormones that occur essentially in the body can increase the growth of some breast cancer. Letrozole works by decreasing the amounts of these hormones in the body. This prescription is meant to be used simply by women who have already stopped menstruating .
Off-label use: It have been within use for the use of ovulation induction by fertility doctors since 2001; having smaller amount side-effects than clomiphene citrate (Clomid(R)) for the patient. A Canadian study presented at the American Society of Reproductive Medicine 2005 Conference suggests that it may increase the risk of birth defect compared with a control group, however a more detailed follow-up study found no principle for concern when letrozole is used for ovulation induction.
Consult your doctor.
Please see the web page for more details on Clomifene (generic name) and Clomid (brand name) Letrozole
The two work by two different routes to the same finish off.
The Femara stops estrogen production in abundant tissues leading the hypothalamus (sensing smaller quantity estrogen) to produce a bigger signal to the pituitary to send a bigger signal to the ovary to ovulate.
The Clomid works by blocking estrogen receptors within the hypothalamus in demand to get one and the same response.
Your doctor has started at the establishment doses to see which has a better response for you. She/He is attempting to indivualize your treatment.
It depends on you, and your response to the medication, not which medicine is better for the hoi polloi.
Old OB Doc
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