Why do allergies motive itchiness?

I am interested in the out of the ordinary mechanism that cause itchiness in an allergic hypersensitivity. I am aware that a Type I hypersensitivity reaction (ie. allergic reaction) is due to flagstaff cell degranulation causing histamine release. I am looking for the steps that follow prevailing to the itchiness (ie. proteins, receptors...) and any biological reason/advantage for this. Thanks!


Answers:    OK, the steps that follows:

>>Following the histamine release,it leaks into the surrounding tissues.

>>Histamine after causes "itch sensation" which sensation is received by "itch receptors" and transmitted through slow-conducting unmyelinated C-polymodal and possibly type A delta nociceptive neurons next to free nerve ending found near to the dermal- epidermal T-junction.

>>The sensation is transmitted to the central distressed system as itchiness.

>>As a quick response of motor nouns, the tendency is to rub or cut into the itchiness.

>>In allergic reactions,histamine cause inflammation, redness (erythema) and itching (pruritis) on the skin surface as an immune defense works. It is an alarm that body's systems are so overloaded with toxicity.

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