What are C3 and C4 level?
Answers: "PA-C" has the complex answer which may be difficult for you if you don't own a medical background.
The "C" or "Complement" force is a series of biochemical reactions that are slice of our immune response system - more specifically dealing with inflammation. Sometimes the body is responding to an outside threat such as an infection, and sometimes the body attacks itself when the immune system is not functioning in general. C3 and C4 are elements of the inflammatory response. Measuring these add pieces to the diagnostic puzzle. It can enlighten us whether the immune system is activated, but it doesn't say aloud what the precise cause may be. This is tricky stuff to explain simply.
MD - Internal Medicine
C3 and C4
Sample requirements: 5-10 ml clotted blood.
Raised level of C3 and C4 levels are found contained by acute phase reactions and within chronic inflammation. Low C3 and C4 levels may crop up in patients beside SLE (systemic lupus erythematosus) particularly next to renal involvement.
Low C3 levels are found contained by patients with membrane proliferative glomerulonephritis or partial lipodystrophy associated beside the presence of C3 nephritic factor.
Low C3 levels, which return to average in convalescence, are associated beside acute post-streptococcal glomerulonephritis.
Low C4 levels go down in patients next to angioedema or cryoglobulinaemia.
Single point determinations of C3 and C4 are of limited worth and serial measurements are recommended.
Normal range C3: 0.7 - 1.7 g/L, C4: 0.13 - 0.43 g/L.
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