What are the disadvantages and advantages of being competent to artificially increase EPO levels contained by blood?
Answer:
Increased EPO levels contained by blood means increased red blood cell production.
This is commonly beneficial if used to treat anaemia, particularly anaemia associated near renal failure (and hence decrease EPO production).
In normal subjects, increased red cell production could lead to polycythaemia with attendant risks: blood clots (DVT/PE), strokes, kidney let-down...
Additionally there is the (incredibly rare) unpredictability of allergic response. Unlikely to be true allergy to the erythropoietin, it may well be a hypersensitivity to some of the preservative or other materials incorporated in the administered formulation.
Just lately (March '07) there have been an FDA public form release about EPO increasing tumour sizes!
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