Why will protease inhibitor work against retovirus to stop viral replication?




Answers:    Most things with -ase are enzymes. Protease is an enzyme that the HIV virus uses when replicating itself. Specifically it cleaves the mRNA into individual virus genomes. Without it the Virus cannot create copies, which stops the infection. However HIV is a retrovirus and as such uses the enzyme reverse transcriptase, which is prone to errors, it has no 3'-5' exonuclease leisure. Because of this HIV will mutate at a very prompt rate, and can become immune to any single protease inhibitor, so it is recommended that many are used surrounded by conjuction, as well as other drugs, AZT is an example.

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