Syphillis Detection?
2.) After inactive stage, the symptoms occurs again and duplicate bacteria strands arises but why are the symptoms different from formerly? Why are they much worse than before?
Answer:
1. T. pallidum have been nickname by microbiologists as a 'stealth' microbe..as it lacks epitopes (it was greatly few targets) on its surface that can be bound by antibodies...hence they escape the immune response because we can't attack it.
Also, it occupies immuno priveledge sites (ie contained by the genitals, testicles..) where the immune system does not attack.
During latency, not much is agreed yet what it does..but it is suspected that they experience changes surrounded by what little surface epitopes it has to further evade theimmune system and spread into other organs
2: It cause worse disease after latency because it has disseminated (spread) to other organs..so primarily instead of just attacking the genitalia, it starts attacking everywhere else..consequently causeing worse disease.
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