Lorazepam query?

I had a merciful that was surrounded by sever respitory distress, breathing <3 per min, and we were competent to reverse this with Narcan. Later contained by the hospital the only entry that came posterior in his blood work be benzodiazepines. It turned out his wife had Lorazepam at home that she one-time to mention. He also had alot of Alcohol contained by his system. I thought that Narcan only worked on Opiate base drugs. If it works also on Benzos, does it work on all Benzos or simply Lorazepam?


Answers:    This is a difficult question to answer but benzodiazepines can in truth have an effect at the opioid receptors any by enhancing the endogenous opioid system, or by direct agonist effects at the receptors. For example, in vitro, midazolam (Versed) surrounded by addition to its hum at the GABA sites, is a weak agonist at the delta-opioid receptor and Midazolam, Diazepam and Chlordiazepoxide are kappa-opioid agonists. The mu-receptor is unmovable of course. (This study be done with intrathecal benzodiazepines)
The alleged beneficial effects of naloxone within non-opioid poisoning probably reflect the involvement of endogenous opioids within the depressant action of benzodiazepines and ethanol.

Hope this help,
AJ

(sidenote: there is an even stranger bag of a 14 year old boy who be given Lorazepam after 4 or 5 days of being on Morphine, and Lorazepam in fact displaced Morphine from the opioid receptors putting the patient within withdrawal!)

EDIT: Found this surrounded by my notes:
Naloxone have some activity as a GABA antagonist and may thus enjoy convulsant activity. However, this is promising to be at much higher concentrations that those encounter clinically (Dingledine et al., 1978), since in mice a dose of 100 mg/kg be required to produce convulsions.
narcan is an adverse for many meds

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