Depression. Serotonin or norepinedephrine?
I seriously want to know what is the true cause of depression. I know that it is due to the discrepancy of neurotransmitter in the brain but which transmitters is it?
Also, in attendance are many drugs available to treat such a symptom. However, it is also specified that SSRI and NASSA. One of them is an inhibitor of Serotonin while the other increases the Serotonin in the body. So, how are they related?
Anyone who have an extensive understanding of this topic is welcome to give an answer. Thanks.
Answer:
I do hold a little intellectual capacity of this subject so i will try to shed some light:
Depression have been related to serotonin due to dense amounts of serotonergic nerve cell which are found in areas of the brain that own to deal next to mood (such as amygdala, medulla, pons, basically most of the midbrain). Serotonin also plays a influential role beside other neurotransmitters such as dopamine and GABA (but thats another story).
As for norepinephrine, this is a neurotransmitter that is connected to euphoria, focus, among other activities, but increase within this chemical would give someone a boost of euphoria (much close to when drinking a cup of coffee or taking an amphetamine). So drugs which increase levels of this chemical within the body may aid in treating depression because of those aforementioned attributes.
This is a extraordinarily difficult question to answer surrounded by only a few words so i would direct you to read up on serotonergic and adenergic receptors/cells, as powerfully as review neuroanatomy and how the placement of these cells next to high density of these types of receptors might play a role contained by depression (midbrain).
but no one know (even at the molecular level) exactly what causes depression, if we know that we could design a drug that specifically targets a place contained by the brain that regulates our depression/mood. Most likely their is not one spot, nor is their purely one type of depression. Something else you might want to look into are cortisol levels and its affects on depression, i be taught surrounded by a psychology class during my undergrad years that this chemical has be correlated to depression.
There is not ONE TRUE SINGLE cause of depression.
isn't the inhibitor of Serotonin in actual fact an SSRI - Serotonin Re-uptake Inhibitor? by inhibiting re-uptake, it leaves more Serotonin in the brai to be used.
Some nation need the SSRI, others requirement the other neurotransmitter..
Some need both.
Neurotransmitters play a slice, but other factors also affect depression. The track people ruminate about themselves and their lives play a big role surrounded by depression for some people. Thinking things approaching I'm not good ample, I'm stupid, no one like me, etc. can contribute to or even cause depression. Retraining yourself to ponder positively can drastically reduce/eliminate depression for some people.
I've taken an SSRI and I've done the retraining entry at different points in my duration. Both have worked okay for me.
The SSRI keeps the serotonin from mortal absorbed hindmost into the neurons so that more remains in the synapses.