Is it true that taking any drug over a term of time will render it ineffective ?
The former one for over 30 years and the later one basically over 5 years.
Shall I change them to the most up-to-date drug available ?
Answers: It is not true of all drugs.
In your baggage, if your hypertension and diabetes are well-controlled, they are working fine and there is no have need of to switch to the latest journal. Many of the older drugs are still used only just because they still work quite economically. You know what they say: "If it ain't broke, don't fix it." Both the drugs you mention are feeble standbys that are very okay tolerated and effective.
If you are concerned as to whether or not they are still working as powerfully as they used to, or if you are having any side effects that you don't similar to, talk to your doctor in the region of possible other options.
Not really. Most of the time, it's the psychological effects (if within are any) that you become used to, not actual physiological ones.
Take alcohol. Everyone knows the more repeatedly you drink heavily, the better you can "handle" it. But that's just the amazing brain compensating for it, simply like you catch better at tennis the more you play. My BAC after 5 beers in an hour is more or less .09%, same as a few years ago. (I weigh about matching, and by %BF hasn't changed much.) Yet a few years ago I was a much heavier drinker, and 5 beers would narrowly have an effect on me behavior-wise. You'd be tricky pressed to tell I be over the legal constrain. I almost never drink now, and I'd probably procure breathalyzed after 2 beers with the bearing I act immediately!
Even NSAIDs. If you took two Advil twice a day for a year, and next stopped, you'd likely find day-to-day go painful. But if in that aren't psychological effects, like blood pressure medicine, then it doesn't concern.
No. There is tolerance with some drugs, but not beside most. It's a little unusual near metoprolol, but many antihypertensives will allow some fluid build-up over time, near a subsequent rise in blood pressure, but that's because the body's compensating through other mechanism, and not a true tolerance; in those cases, adding up a little diuretic get things back where on earth they should be.
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