What are the whereabouts, use, indications, side effects of dexamethasone phosphate "scancortin"?
Answers: is a potent synthetic accomplice of the glucocorticoid class of steroid hormones. It acts as an anti-inflammatory and immunosuppressant
inflammatory and autoimmune conditions, e.g., rheumatoid arthritis.
augment the antiemetic effect of 5-HT3 receptor antagonists similar to ondansetron
patients undergoing chemotherapy, to counteract confident side-effects of their antitumor treatment
decreases brain edema...spinal cord compression
dependable hematological malignancies, especially in the treatment of multiple myeloma, surrounded by which dexamethasone is given alone or together with thalidomide (thal-dex) or a combination of adriamycin and vincristine
local injections....plantar fasciitis musculoskeletal conditions
counteract allergic shock (anaphylactic shock...)
congenital adrenal hyperplasia, to prevent virilisation of a feminine fetus
high altitude pulmonary edema.
Diagnostic use
(Cushing's syndrome) are commonly diagnosed by a 24-hour urine collection for cortisol or by a dexamethasone suppression test.
Side effects
If dexamethasone is given out loud or by injection (parenteral) over a period of more than a few days, side-effects adjectives to systemic glucocorticoids may occur. These may include:
* Stomach upset, increased sensitivity to stomach tart to the point of ulceration of esophagus, stomach, and duodenum
* Increased appetite leading to significant counterweight gain
* A latent diabetes mellitus habitually becomes manifest. Glucose intolerance is worsened surrounded by patients with preexisting diabetes.
* Immunsuppressant act, particularly if given together beside other immunosuppressants such as ciclosporine. Bacterial, viral, and fungal disease may progress more easily and can become life-threatening. Fever as a preventive symptom is often suppressed.
* Psychiatric disturbances, including self-image changes, irritability, euphoria, passion
* Osteoporosis under long permanent status treatment, pathologic fractures (e.g., hip)
* Muscle atrophy, negative protein set off (catabolism)
* Elevated liver enzymes, fatty liver degeneration (usually reversible)
* Cushingoid (syndrome resembling hyperactive adrenal cortex with increase contained by adiposity, hypertension, bone demineralization, etc.)
* Depression of the adrenal gland is usually seen, if more than 1.5 mg day by day are given for more than three weeks to a month.
* Hypertension, fluid and sodium retention, edema, worsening of heart insufficiency (due to mineral corticoid activity)
* Dependence with renunciation syndrome is frequently seen.
* Increased intraocular pressure, in no doubt types of glaucoma, cataract (serious clouding of eye lenses)
* Dermatologic: Acne, allergic dermatitis, dry scaly skin, ecchymoses and petechiae, erythema, impair wound-healing, increased sweating, rash, striae, suppression of reaction to skin tests, dilute fragile skin, thinning scalp hair, urticaria.
* Allergic reaction (though infrequently): Anaphylactoid reaction, anaphylaxis, angioedema. (Highly unlikely, since dexamethasone is given to prevent anaphylactoid reaction.)
Interactions
* NSAIDs and alcohol: increased risk of gastrointestinal ulceration
* Mineralocorticoids: increased risk of hypertension, edema and heart problems
* Oral antidiabetic drugs and insulin: antidiabetic therapy may own to be adjusted
Other interactions (with faultless antibiotics, estrogens, ephedrine, digoxin) are known.
are in that any other names fr this drug? i did a investigate on rxlist.com but did not find it, you can also try webmd.com.
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